Lung Health Instititute | Should You Consider Using Red Sage for COPD?Health NewsTwo Experimental COPD Treatments Promesa of the Show New research shows that a specific type of white blood cells can be manipulated to relieve the body's immune response to COPD. Two experimental therapies can control chronic inflammation in patients with chronic obstructive pulmonary disease (COPD). One of the proposed therapies is found in the red sage, a Chinese medicinal herb that has been used for centuries to treat problems with menstruation, heart disorders and blood circulation. Researchers from the United Kingdom say that Tanshinone IIA, a compound naturally found in the red sage, could act as a powerful weapon against chronic inflammation by controlling the response of a certain type of white blood cells. Neutrophils are the most abundant type of white blood cells in the human body. They fight infections and help increase the immune response of other cells. But while they are usually beneficial, they can create lasting tissue damage in people with autoimmune disorders. Researchers believe that they can help reduce inflammation in chronic conditions such as COPD by removing damage-causing neutrophils. The teams of the University of Edinburgh Medical School in Scotland and other facilities discovered the beneficial properties of the red sage as they tested the inflammatory response in the zebrafish, a common and translucent fish found in pet stores. It tested the effects of thousands of compounds in the immune responses of fish whose tails were injured. Because fish were genetically modified so that their neutrophils would shine green, researchers could see inside the fish as their bodies responded to their injuries. They found that Tanshinone IIA had the greatest impact on reducing the inflammatory response either by driving neutrophils away from the site or causing cell death. Researchers, who published their findings in the journal, say that aiming at these neutrophil cleaning mechanisms can be useful in creating more effective anti-inflammatory drugs. "The fact that Tanshinone IIA is already used in traditional Chinese medicine makes it likely that future drugs containing this compound are not toxic to humans," the researchers concluded. One of the problems with anti-inflammatory drugs is that they cover the entire body, often with unwanted side effects. Researchers at the University of Illinois in Chicago (UIC) have found a way to do so using nanoparticles—a microscopic particle—to prevent neutrophils from coupled with the walls of the blood vessels. The UIC research team has designed a nanoparticle embedded with an anti-inflammatory medication to target neutrophils. "The nanoparticle looks a lot like a Trojan horse," said Asrar B. Malik, a distinguished professor of the Schweppe family and head of pharmacology at UIC College of Medicine in a press release. "It binds to a receptor that is found only in these activated and sticky neutrophils, and the cell automatically wraps everything that is attached there. Because circulating neutrophils lack these receptors, the system is incredibly accurate and is directed only to immune cells that are actively contributing to inflammatory disease." They tested these nanoparticles in real time at times induced with vascular inflammation seen in COPD. The researchers used piceatannol, a metabolite of a compound found in red wine, and found that neutrophils separated from each other and left the walls of the blood vessels. Effectively neutralized, they were prevented from contributing to the process of inflammation. The results show, Malik said, "that nanoparticles can be used to deliver medications in a very specific and specific way to activate immune cells and could be designed to treat a wide range of inflammatory diseases." His findings were published in the last issue of the magazine. Read this next series of words
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